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These findings highlight the functional overlap among iron metabolism, lipid peroxidation, and amino acid dysregulation in PD and suggest that maintaining cellular redox balance and controlling LPO are essential for preventing ferroptosis and delaying PD onset (248)

Scavenger receptors Lipoprotein receptors that remove modified lipoproteins (for example, acetylated or oxidized low-density lipoproteins) and other negatively charged macromolecules from the blood

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Based on this research, Perlmutter and his colleagues developed a pipeline of drugs that stimulate degradation of the misfolded protein and prevent liver damage in a mouse model of ATD