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Similarly, another study showed that tIRI triggered oxidative stress, thereby upregulating the phosphorylation of p53 and the expression of its downstream proapoptotic factor Puma, resulting in increased apoptosis

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Prognostic value of the metabolic syndrome in essential hypertension

After that, the solvent was evaporated under reduced pressure and the crude product was purified by flash column chromatography to get compound that contains the first functionality