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Strikingly, the CREB inhibitor 666-15 as well as another small molecule, the PI3K/AKT inhibitor GSK690693, attenuated chemoresistance in the cancer cells with ZIP10 overexpression

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The dose was then increased to 25 mg kg 1 per day for the next 23 days and further escalated by 5 mg kg 1 per day to a final dose of 45 mg kg 1 for the remaining duration of treatment

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