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There are days when she wakes up and would rather close her eyes again

During treatment, the laser explodes the ink under the skin and then through a variety of mechanisms, the body clears that ink through its immune system

Importantly, the presence of side effects may also serve as a clinical cue that the appetite-regulating mechanism is active , though any severe or persistent symptoms warrant reevaluation of dose or co-therapy timing

Necessary background knowledge of diseases and established clinical procedures for understanding the recommendations are presented in Notes, while information that may be clinically useful but for which evidence remains insufficient is included in Columns, based on the current state of evidence