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We included original research articles, randomized controlled trials, meta-analyses, systematic reviews, and high-quality narrative reviews published in peer-reviewed journals

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It has been shown that when carbazole is present in human skin, for example in tattoo ink, prolonged exposure to sunlight resulting in photosensitized carbazole causes downregulation of antioxidant genes (hmox-1, keap-1, nrf-2, and bcl2) in HaCaT cells and of course an increase of ROS, with consequent apoptotic cell death (59)