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Triglycerides, a blood fat marker linked to cardiovascular disease, dropped by over 40% in retatrutide participants at the higher doses

Given the positive effects in multiple animal models of aging and neurodegeneration, including models of AD, clinical trials for rapamycin in AD are underway (NCT04200911, NCT04629495)

PMID: 42010017 Thorac CancerIdentification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer

At the metabotropic level, Pb 2+ -induced downregulation of mGluR5 expression and interference with mGluR1/Ca 2+ -dependent signaling cascades further compromise synaptic plasticity mechanisms such as LTD and intracellular calcium signaling