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Inserting the given values into the equation, This result makes sense because the [A ]/[HA] ratio is between 1 and 10, so the pH of the buffer must be between the p K a (3.75) and p K a + 1, or 4.75

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

Comparison of BDNF-boosting peptides The following comparison helps illustrate the relative strengths and research maturity of each compound

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