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Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action

Specifically, granulocytes (such as eosinophils) possess a high concentration of adrenergic receptors and a low concentration of cholinergic receptors on their surfaces, while lymphocytes (including macrophages) have a high concentration of cholinergic receptors and a low concentration of adrenergic receptors present on their surfaces [81] (Figure 2)