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Another arginine transporter, CAT-2 ( SLC7A2 ), is highly expressed in BRAF (v-raf murine sarcoma viral oncogene homolog B1) inhibitor-resistant melanoma, displaying metabolic reprogramming from glucose to arginine dependence (Li Y

This formula harnesses the synergy of creatine monohydratethe most studied form of creatineand a naturally occurring metabolite known as beta-hydroxy-beta-methylbutyrate (HMB), the latter of which helps reduce muscle damage and muscle protein breakdown

doi: 10.1016/j.bmcl.2017.11.046

*Correspondence: Huili Zhu, [email protected] These authors have contributed equally to this work This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers