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Activation of the NMDAR causes the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase to produce superoxide, which conducts signal transduction between neurons

IAC-S010759(OPi) has same functional backbone but has been attenuated conduction (Vashisht Gopal et al., 2019), a directed CI inhibitor, was shown to significantly inhibit the growth of melanoma models with multiple MAPKi resistant BRAF mutation in vivo at tolerated doses, and strongly inhibited proliferation and induced apoptosis in OXPHOS-dependent brain cancer and acute myeloid leukemia (AML) models

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Lemos IDS, Torres CA, Alano CG, Matiola RT, de Figueiredo SR, Padilha APZ, De Pieri E, Effting PS, Machado-De-Avila RA, Reus GZ, Leipnitz G, Streck EL (2024) Memantine improves memory and neurochemical damage in a model of maple syrup urine disease