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The higher prevalence of insulin resistance and metabolic syndrome in older people compared with younger population may also be attributable, at least in part, to the decline of serum and tissue IGF-I concentrations with advancing age[55, 307]

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While several studies suggest that chronic circadian disruption from NSW may modestly elevate BC risk, findings have been heterogeneous and at times conflicting, reflecting variation in study design, exposure definitions, and adjustment for reproductive and lifestyle factors (Tables 1011)

10.1038/nature12681 12 DingB.-S.NolanD