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We demonstrated using NMR that FOXO4DRI peptide competes with FOXO4 for p53 binding and therefore can efficiently interfere with the FOXO4 p53 interaction Mechanistically, FOXO4DRI promotes nuclear exclusion of active p53

27 Competition in the distribution of 5,10-methyleneTHF between thymidylate biosynthesis and remethylation pathways indicates that common MTHFR variants (C677T and A1298C) may also alter activity of the multienzyme complex in thymidylate production during DNA repair

A Simple, Robust, and Low-Cost Method to Produce the PURE Cell-free System