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Pro-resolving lipid mediators (Hsiao et al., 2015), PDE2 antagonists (Snell et al., 2013), antibodies directed against inflammatory cytokines (Barnes, 2018), are among the other several approaches which, at the moment, did not demonstrate a relevant clinical benefit when tested in clinical trials despite their success in animal models

As the liver plays a crucial role in glutathione metabolism, optimizing its function can indirectly contribute to higher glutathione levels

Targeting both A fibrillogenesis and fibril degradation represents an emerging strategy for destroying pathological protein aggregates