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383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)

dNTP pools in replicating cells are at a low steady-state concentration and are rapidly turned-over, indicating that the precursors are polymerized into DNA almost immediately upon their production (Rottgen and Rabes, 1989)

For the Immunometabolic panel, targets were allocated to specific heavy-metal isotopes following the sensitivity of the mass cytometer (e.g., placing lower abundance targets on higher sensitivity channels) and to avoid potential spillover, as previously outlined 92