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Capsaicin, the main source of heat in hot peppers, alters levels of IL-6, IL-10, TNF, NOx, and MDA (225), and the natural sugars in avocado alter gene expression of IL-1, IL-6, and IL-8 (227, 228)

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The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes