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911,13,14 Organelle swelling leads to cellular necrosis and the release of mitochondrial contents, such as apoptosis-inducing factor (AIF) and endonuclease G (EndoG), which in turn migrate to the nuclei and cause DNA fragmentation

Age related distribution of 4-hydroxy 2-nonenal immunoreactivity in human retina

The aldehyde group can then be conjugated to molecule of choice through, e.g., hydrozino-Pictet-Spengler chemistry.' [0449] Many other procedures and linker molecules for attachment of various compounds including radionuclide metal chelates, toxins and drugs to proteins such as antibodies are known {see, e.g., European Patent Application No

Glutathione, the body's master antioxidant, defends your cells against the oxidative stress that accelerates aging