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So, we can state that it has been demonstrated as an important medication because of its multidirectional effects

Thus, therapeutic strategies designed to improve the recovery from exhaustion, such as combination checkpoint blockade (e.g., anti-PD-1 plus anti-LAG-3) or the development of novel bispecific CAR-T cells targeting PD-L1 and other coexpressed receptors, are fundamentally based on this principle [238,239,240]