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In the kidney, GLS catalyzes the hydrolysis of glutamine to ammonia and glutamate

DOI: 10.1021/ol070674f

NAC can inhibit ferroptosis by replenishing intracellular glutathione and supporting GPX4 activity, but its broad mechanism of action makes it difficult to attribute benefits specifically to ferroptosis inhibition ( Key hurdles for clinical translation of ferroptosis inhibitors include ( 5.2 Gut microbial modulators Understanding the role of gut microbiota in ferroptosis opens up exciting possibilities for new therapeutic strategies

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