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Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

The Lancet Neurology, 14(1), 103113

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In CRC, SHMT2 has been shown to bind competitively to the cytosolic p53 protein, thereby sequestering the E3 ubiquitin ligase HDM2(Human double minute 2), thereby inhibiting autophagy and conferring resistance to 5-fluorouracil (5-FU) chemotherapy [104]