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This is another reason the medically supervised pathway matters

Chronic inflammation contributes to a variety of age-related diseases, such as neurodegenerative disease, cancer, infectious disease, and autoimmune diseases

We also agree with the commenter that the proposal for calculating the payment limit for a biosimilar for which negative or zero ASP data are reported for all NDCs is dissimilar from the methodology provided in statute for circumstances when positive manufacturer's ASP data is available