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Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study

[] Data sources and search strategy Multiple databases, including PubMed, Scopus, Cochrane Library, and Web of Science (WOS), were searched until 31 March 2025 [updated: 1 April 2025]

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Major drug Interactions: Decongestants Local anesthetics w/ sympathomimetics Antihypertensives CNS depressants Drugs metabolized by P450-2D6 Concomitant use of MAOI's can cause potentially fatal hyperpyretic crisis & seizures History: The therapeutic & commercial success of phenothiazine antipsychotics initiated a large scale search for more effective antipsychotics during the early 1950's