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Furthermore, double KO mice receiving three weekly intravenous injections of hCitrinmRNALNPs showed an increased preference for voluntary sucrose consumption, indicative of a reduction in the canonical aversion to carbohydraterich foods associated with CD [118]

This stimulates the production of excessive testosterone by thecal cells, disrupting the hypothalamic-pituitary-ovarian (HPO) axis, ultimately affecting dominant follicle generation, follicular dysfunction, and ovarian interstitial cell fibrosis (51, 52)

Khodagholi F, Eftekharzadeh B, Maghsoudi N, Rezaei PF (2010) Chitosan prevents oxidative stress-induced amyloid formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-B

While no model fully recapitulates dry AMD, these two acute in vitro models effectively capture several key features observed in the RPE during the progression of AMD, thereby establishing a relevant platform for evaluating potential therapies for AMD and GA