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While liposomes can encapsulate both hydrophilic and hydrophobic drugs, their loading capacity for highly lipophilic drugs might be lower compared to NLCs [179]

However, it is noteworthy that, while upregulation of glutamine metabolism is a phenomenon present in many cancer cells, recent studies have shown a decrease in glutamine metabolism in cholangiocarcinoma, glioblastoma multiforme, liver hepatocellular carcinoma, and thyroid carcinoma, demonstrating tissue heterogeneity in glutamine metabolism [40]

Oncotarget (2015) 6(16):1426073

These autoantibodies can also affect pregnancy, causing an increased risk of miscarriage