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We have compared the values of differential protein profiles in seminal plasma in both oxidative and physiological conditions

Disclosures: ATSUSHI UMEDA: EA Pharma Co., Ltd.: Employee, YASUKO OWADA: Nothing to Disclose, KENICHI FURIHATA: Kissei Pharmaceutical Company: Advisor, SHUICHI TSURUOKA: Nothing to Disclose, Atsushi Nakajima: Nothing to Disclose, RYOSUKE MIKAMI: Nothing to Disclose, MASAKAZE OAKU: Nothing to Disclose, TAKUYA YAMAMOTO: Nothing to Disclose, TETSUO YANO: Nothing to Disclose, YUJI KUMAGAI: Nothing to Disclose 593 DNA METHYLOME ANALYSIS REVEALS EPIGENETIC ALTERATION OF COMPLEMENT GENES IN ADVANCED MASLD Won Kim 1 Young Ho So 1 YONG JIN JUNG 1 Sae Kyung Joo 1 , 1 Boramae Medical Center Background: Blocking the complement system presents a promising strategy to impede the progression of metabolic dysfunction-associated steatotic liver disease (MASLD)

Nikolsky sign is manifested by a dermal-epidermal cleavage when applying tangential pressure to apparently intact skin, even this sign was not pathognomonic but also helpful to diagnose this condition

Therefore, the binding affinities and stability of crocin with AKT1 and TP53, while promising, need to be validated through experimental studies