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J Control Release 297:3947

While it was shown to slow cancer cell proliferation in vitro and in xenografts [38] , its moderate potency (IC 50 = 3.3 mol/L), poor metabolic stability and low solubility, limit its potential use in the clinical setting [39]

Standardized dosing protocols, validated outcome measures, and comprehensive safety monitoring would establish the evidence base necessary for informed clinical decision-making

Patients included in the study gave written informed consent and specimen collection was approved by the local Institutional Review Board of Charit University Medicine, Germany (EA4/019/12), the Ethics Committee of the University of Rostock, Germany (A 2009/34) and the Institutional Ethics Committee of the Medical University of Graz, Austria (24-402 ex 11/12)