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This explains the relationship between oxidative stress and epileptogenesis as well as the role of antioxidant-based therapy in the management of epilepsy (Geronzi et al

STORM Therapeutic based in the UK, developed the first METTL3 small molecule inhibitor STM2457 for leukemia treatment and advanced it into Phase I clinical trials [67]

It is also unlikely that the Fe-porphyrin-mediated scavenging role of H 2 would account for all effects seen when, for example, the localization of the production of OH and the diffusion of H 2 from outside the cells - as it is often applied exogenously - are considered