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The cellular effects of this hostile environment depend on factors such as cell type, presence of surface receptors, mechanism of transduction and levels of antioxidants [7]

10.1016/S0006-291X(02)00768-4 68

Importantly, this regulation cascade can be exploited by targeting YBX1 to block AMPK protein synthesis and targeting GLUT1 to induce energy stress, which synergistically blunts tumor growth in vivo