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Interestingly, the TME not only facilitates drug liberation, but could also be manipulated by metal nanomedicines (Zhang et al., 2020a

"Depakin - Banca Dati Farmaci dell'AIFA" [Depakin - The AIFA Medicines Database]

Separate research has looked at how it promotes dermal healing in skin models

Overall, these investigations elucidated the therapeutic potential of luteolin, palmitoylethanolamide/luteolin combinations, and compounds derived from natural products in the context of neurodegenerative diseases, particularly PD and HD