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We thank the MPI-AGE, the Max Planck Society, the Leibniz Institute on Aging, the FLI, the DFG Collaborative Research Center (SFB 1310) and a European Molecular Biology Organization postdoctoral fellowship (H.M.D.) for the financial support for this project

Activation of alpha-1 leads to the (i) contraction of the iris dilator and Mullers muscles, leading to mydriasis and lid retraction, (ii) vasoconstriction causing the restriction of blood flow to the ciliary muscle, and (iii) reduced aqueous humor production [215]

Standard reconstitution uses 2 mL of bacteriostatic water per 5 mg vial, producing a concentration of 2.5 mg per mL or 0.25 mg per 0.1 mL (10 units on an insulin syringe)

B Vitamins help with energy metabolism, and Biotin helps to maintain healthy hair