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Only some hopeful sEH inhibitor candidates are subjected now to clinical trials such as GSK2256294A in Phase-I and AR9281 in Phase-II against chronic obstructive pulmonary disease (COPD) and hypertension

PMID: 17351113

doi: 10.1038/s41538-024-00348-w 188

This suggests that when aiming to enhance ATP production by increasing TCA cycle flux, it is essential to consider the interplay between glycolysis and the TCA cycle, as excessive TCA cycle activity may suppress glycolysis