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Also, our work is the first (as far as we know) to pinpoint a potential targetable cellular mechanism, where these metabolic changes clearly affect lymphocyte activation and likely the immune response generally, and if systemic could explain the prevalence of fatigue and other symptoms in these two syndromes

found that butyrate, a short-chain fatty acid derived from gut microbiotawhose levels are notably diminished in EMS patientsheightens the susceptibility of EESCs to Erastin-induced ferroptosis (62)