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()-Phen illustrates how a drug that was opportunistically developed to supplement cholinergic activity in AD, and that has proven well-tolerated and provided a consistent evidence of efficacy [73, 113], can consequent to its more recently discovered important broad spectrum of pharmacological actions be optimized to not only provide potential efficacy in TBI, but also provide a pharmacological tool to understand how TBI can lead to AD

Boy K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Eichmann A (2022) Endothelial Unc5B controls blood-brain barrier integrity

The processes of lipid peroxidation leading to the generation of lipid peroxidation products can disrupt membrane integrity, fluidity and permeability, potentially leading to inflammatory responses and cell dysfunction 90