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Both YAP1 and ZEB1 are potential predictors of sensitivity to ferroptosis inducers GTP cyclohydrolase (GCH1)

Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, et al

7E2709A)

The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45