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The cells are a major source of fibronectin, but also upregulate many ECM proteins in response to mechanical stressors (pressure, stretch) under both in vivo and in vitro conditions (e.g., tenascin, laminin, collagens, elastin and thrombospondin) (e.g., Figure 14) together with genes associated with cell motility and migration (gelsolin, LIMBP1, periplakin) and downregulation of integrin genes (92, 98)