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Current evidence indicates that vitamin deficiencies, particularly vitamin D, folate, and B12, are prevalent in BD and may influence clinical severity, treatment response, and metabolic comorbidities

This action effectively reverses tau hyperphosphorylation and promotes its degradation through the lysosomal pathway, thereby mitigating tau-mediated intracellular transport impairment, axonal and synaptic damage, and neuronal death

Auxiliary exogenous components, mainly including strong cationic polymers and their derivatives, often also cause serious cytotoxicity to normal organs 15,16

reported that daily peritumoral injection of methionine improves ACT efficacy in murine tumor models ( GCN2-Methionine-ROS metabolic circuit: role in tuning T cell function GCN2, methionine, and ROS each play independent yet integrated roles in tuning T cell responses to tumors, such that modulation of one pathway inevitably influences the others