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Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects

Witschi A, Reddy S, Stofer B, Lauterburg B H

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Medium-chain fatty acids may play a central role in the KD, which may regulate mitochondrial metabolism in astrocytes and have positive effects on the brain such as accelerated glycolysis, enhanced lactate shuttle, and accelerated ketone body production (190)