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Mitchell KG, Farooqi A, Ludmir EB, Corsini EM, Sepesi B, Gomez DR, Antonoff MB, Group MD

This is achieved through the maintenance of mitochondrial cysteine metabolism in the form of Fe-S cluster synthesis and depends on the catabolism of GSH by CHAC1 (Fig

Besides the cytotoxicity pathways discussed above, Se-induced cytotoxicity against malignant cells might also be the result of ROS generation, as in the case of injection of biogenic SeNPs into the abdominal cavity of mice following their inoculation with highly malignant H22 hepatocarcinoma cells [294]

For instance, T-DXd combined with durvalumab in the DESTINY-Breast07 trial, as well as sacituzumab govitecan in combination with atezolizumab in NSCLC and TNBC, are under clinical evaluation to assess the synergistic potential of this approach (NCT05382286) [572576]