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Small animal models of hypertension have many features of human HFpEF and may help elucidate some aspects of HFpEF pathogenesis

Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons

113,114 Substrates recruited by Yos9 and Hrd3 are delivered to a complex containing Hrd1 and Der1, where the substrate associates with a groove in Hrd3 and a Yos9 lectin domain (on its luminal side) while its loop is inserted into the ER membrane