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Di ChiacchioIMGmez-AbenzaEPaivaIMde AbreuDJRodrguez-VidalJFCarvalhoEEet al

340 The phosphate group prevents binding between the guanidine group (Arg side chain) and AuNPs, leaving Cys to interact with gold

However, this perception began to shift in 1921 when Otto Warburg demonstrated that tumor cells preferentially metabolize glucose into lactate via aerobic glycolysis, underscoring its pivotal role in tumor metabolism [5]