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5.2 Worsening Pulmonary Vascular Occlusive Disease Pulmonary vasodilators may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease (PVOD)

If menstrual irregularity develops or worsens after initiating the stack, measure luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and thyroid function