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141 (2 Suppl): e152Se184S

72 HoL.ZhaoD.OnoK.RuanK.MognoI.TsujiM.et al (2019)

"Circadian regulation of NNMT expression and its role in metabolic homeostasis." Journal of Biological Rhythms, 36(4), 342-356

The design of novel therapeutic agents such as monoclonal antibodies (mAbs), stem cells and genes is currently under way and clinical trials have been attempted, however, the therapeutic efficacy has been greatly limited by the fact that large molecular agents cannot penetrate the blood-brain barrier (BBB)