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Surprisingly, although worms lacking TrxR1 show a molting defect due to an inability to reduce protein disulfides in the old cuticle to allow its removal, but like mouse livers lacking TrxR1 (Rollins et al., 2010

(2.2) In Combination with Oxaliplatin: 1,000 mg/m2 orally twice daily for the first 14 days of each 21-day cycle until disease progression or unacceptable toxicity in combination with oxaliplatin 130 mg/m2 administered intravenously on day 1 of each cycle

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