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The PIEZO2 mutation causing joint deformities reinforces the notion that abnormalities in proprioception may lead to musculoskeletal deformities [ 160 ]

This review article will introduce some of the small molecule drugs that are currently receiving significant attention: Orforglipron Orforglipron is an oral small molecule GLP-1RA developed jointly by Eli Lilly and Chia Tai Tianqing Pharmaceutical Group