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During protein folding stress, the sirtuin SIRT7 also plays an important role by contributing to repressing nuclear respiratory factor 1 (NRF1) activity, a major transcriptional regulator of mitochondrial genes

Comparable to these findings, the immuno-reactivities of both GPx4 and FACL4 were successfully preserved to near the normal levels under ALA treatment during CSD (Figures 2C,F)