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Such insights underscore the need to refine dietary recommendations and design targeted supplementation strategies tailored to different populations

The deletion of the p53 gene alleviates the damage of HS to endothelial cells and inhibits the mitochondrial apoptosis pathway, which in turn proves that p53 translocation plays a crucial role in HS-mediated apoptosis [128]

Acknowledgements The authors would like to recognize the contribution of the specimen donors as well as the research entities who have made these analyses possible