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[3] immune modulatory responses, which involve the reduction of pro-inflammatory cytokine and nitric oxide (NO) production, as well as the promotion of immunosuppressive macrophage (M2) formation [123, 124]

When the intracellular tight junctions do not function optimally, the intestinal mucosa becomes more permeable or leaky, leading to the vicious cycle of inflammation and dysfunction known as leaky gut syndrome, or increased intestinal permeability

We have recently demonstrated that selective neuronal stimulation in the contralesional LCN using optogenetic approaches resulted in robust and persistent recovery after stroke, as stroke mice maintained their improved performance even after cessation of stimulation for 2 weeks [75]

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