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Importantly, it has been observed that nuclear translocation occurs at non-toxic doses of paracetamol and at time points before overt toxi-city is observed

But adding a little supplemental glutamate might help in the meantime

This suggests that there is some component in the ELF or lung that can act as a sensor to titrate the increase in GSH levels to prevent the ELF GSH level from dropping below basal levels

While the chemically induced models of PD, MPTP and 6-OHDA, provide valuable insight into the oxidative stress-related mechanisms of dopaminergic neuron loss in vivo , they do not fully recapitulate PD neuropathology with -syn aggregation (Meredith and Rademacher, 2011