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The difference is architectural, mechanistic, and clinically meaningful

Ann Thorac Surg 108(2):370-376, 2019

FalkowskaMMynarczykMMicunZKonopiskaJSochaK

The phosphorylation of S409/410 on the TDP-43 CTD was identified in patients with TDP-43-induced frontotemporal lobar degeneration (FTLD), as well as highly consistent features in pathologic inclusions 87