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71,72 To account for differences between drugs, such as the 1 AR antagonist activity of carvedilol, we ran sensitivity analyses with each drug removed and found similar risks (data not shown), suggesting that our results cannot be attributed to any single compound

For oral dosing: If intermittent doses are given, the maintenance dose is calculated from: Maintenance dose = Dosing rate Dosing interval (11) (See Box: Example: Maintenance Dose Calculations.) Note that the steady-state concentration achieved by continuous infusion or the average concentration following intermittent dosing depends only on clearance

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although, the effect of the MOR agonist desensitizes and produces heterologous desensitization of KOR responses (KOR responses do not desensitize independent of MOR activation) (Chen et al., 2015)