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NAD + can be generated de novo in the kynurenine pathway, where Trp is oxygenated to N-formylkynurenine by tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO) 31

Certaines tudes explorent aussi son utilisation dans les neuropathies diabtiques et les douleurs nerveuses, avec des rsultats encourageants mais variables

PMID: 68 WidyanandaMHPratamaSKAnsoriANMAntoniusYKharismaVDMurtadloAAAet al

Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H, Mizusawa H (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition